- Title
- Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health
- Creator
- Vashum, Khanrin Phungamla; McEvoy, Mark; Shi, Zumin; Milton, Abul Hasnat; Islam, Md Rafiqul; Sibbritt, David; Patterson, Amanda; Byles, Julie; Loxton, Deborah; Attia, John
- Relation
- BMC Endocrine Disorders Vol. 13, p. 1-8
- Publisher Link
- http://dx.doi.org/10.1186/1472-6823-13-40
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2013
- Description
- Background: animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women. Methods: data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women’s Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression. Results: from 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32–0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates. Conclusions: higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes.
- Subject
- diabetes; Australia; women and zinc
- Identifier
- http://hdl.handle.net/1959.13/1045326
- Identifier
- uon:14444
- Identifier
- ISSN:1472-6823
- Language
- eng
- Full Text
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